Synthesis and Characterization of Some New Theophylline Derivatives
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چکیده
This paper presents the synthesis of some new theophylline derivatives with potential bronchodilatatory properties. The compounds were synthesized starting from theophylline and 8-R-theophyllines (R=Br, NO2, pyrrolidinyl, piperidinyl, morpholinyl, imidazolyl) that were reacted with 4-(2,3-epoxy-propyloxy)-acetanilide. The new compounds, which have not been mentioned in the literature concerning this domain, have been characterized by their physical constants (melting point, solubility) and the chemical structure was confirmed by elemental and spectral (FT-IR, 1H-NMR, 13C-NMR) analysis. The DL50 values of new synthesized theophylline derivatives have been also established.
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تاریخ انتشار 2010